Diabetes Research in Children Network (DirecNet)

Protocol: The Effect of Basal Insulin During Exercise on the Development of Hypoglycemia in Children with Type 1 Diabetes
Status: Closed
Start Date:  
End Date: 11/30/2005
Clinical Trial ID:  
Public Dataset:  Download

The Effect of Basal Insulin During Exercise on the Development of Hypoglycemia in Children with Type 1 Diabetes
 
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This study was done to find out if decreasing the insulin that is received during exercise can make low blood sugar (hypoglycemia) less likely. Fifty-five subjects age 8 to 17 years were seen during two outpatient visits each with a 75-minute exercise session in the late afternoon. The basal insulin rate from the subject’s insulin pump was continued during the exercise on one exercise day. On the other exercise day, the basal rate was discontinued at the start of exercise and not restarted until the end of the 45-minute post-exercise observation period. A CGMS continuous glucose monitor was used on both exercise days. Blood samples were collected and blood sugar measurements were performed throughout both visits to determine changes in blood sugar levels during exercise. Blood samples were also drawn to measure hormones to see how they are affected.     


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