Diabetes Research in Children Network (DirecNet)

Protocol: Evaluation of Counter-regulatory Hormone Responses during Hypoglycemia and the Accuracy of Continuous Glucose Monitors in Children with T1DM
Status: Closed
Start Date: 05/01/2006
End Date: 04/15/2007
Clinical Trial ID:  
Public Dataset:  Download

Evaluation of Counter-regulatory Hormone Responses during Hypoglycemia and the Accuracy of Continuous Glucose Monitors in Children with T1DM


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This study was done to compare the glucose level at which counter-regulatory hormone responses occur during hypoglycemia in young children with diabetes, with the glucose level counter regulatory hormone responses that occur in older children with diabetes.  Other objectives of this study include to assess signs and symptoms at different glucose levels of hypoglycemia in younger compared to older children, assess whether there is a difference in counter-regulatory hormone response in each age group, and to examine the accuracy of the Guardian-RT during hypoglycemia in children with type 1 diabetes.  Twenty-five subjects age 3 to less than 7 and 12 to 17 were instructed on use of the Guardian-RT and returned approximately 6 days after the enrollment visit for an 18-hour overnight admission to a research unit.  During the hypoglycemia testing, the child’s blood sugar was dropped slowly and blood samples were taken throughout the testing.  Parents were asked to complete a questionnaire regarding whether their child “felt” or “looked” low throughout the testing.



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